A historical overview of peptide chemistry from T. Curtius to E. Fischer to M. Bergmann and
L. Zervas is first presented. Next, the fundamentals of peptide synthesis with a focus on solid …

In the past few years, using microwave energy to heat and drive chemical reactions has
become increasingly popular in the medicinal chemistry community. First described 20 years …

A series of improvements to the standard solid phase peptide synthesis (SPPS) process
allowing for significant gains in product purity along with only a 4 min standard cycle time …

Solid phase peptide synthesis (SPPS) provides the possibility to chemically synthesize
peptides and proteins. Applying the method on hydrophilic structures is usually without …

Microwave energy represents an efficient manner to accelerate both the deprotection and
coupling reactions in 9‐fluorenylmethyloxycarbonyl (Fmoc) solid phase peptide synthesis …

As the range of techniques for microwave heating has expanded, so have the areas in which
it can have a profound impact. Two emerging areas are the application of microwave …

The Fmoc/t-Bu solid-phase synthesis of three difficult peptide sequences (a 9-mer, 15-mer,
and 24-mer) was performed using N, N′-diisopropylcarbodiimide/1-hydroxybenzotriazole …

We present a process for solid phase peptide synthesis (SPPS) that completely eliminates
all solvent intensive washing steps during each amino acid addition cycle. A key …

Prior to the evolution of complex biochemical machinery, the growth and division of simple
primitive cells (protocells) must have been driven by environmental factors. We have …

We have evaluated the effects of microwave irradiation on the solid-phase synthesis of β-
peptides. Sequences designed to adopt the 14-helix, especially those containing the …