During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

Background Old age is characterized by a peculiar low-grade, chronic, and “sterile”
inflammatory state, which has been termed “inflammaging.” This is believed to substantially …

Aging is accompanied by physiological changes affecting body composition and
functionality, including accumulation of fat mass at the expense of muscle mass, with effects …

Obesity is a major public health issue with prevalence increasing worldwide. Obesity is a
well-established risk factor for CVD and mortality in adult populations. However, the impact …

Background Body mass index (BMI) is an inadequate marker of obesity, and cannot
distinguish between fat mass, fat free mass and distribution of adipose tissue. The purpose …

Sarcopenia is defined as a progressive and generalized skeletal muscle disorder
associated with accelerated loss of muscle mass and function, resulting in falls, functional …

We propose in this review that hormesis, a concept profoundly and systematically addressed
by Mark Mattson, has to be considered a sort of comprehensive “contact point” capable of …

Objective This study examined the effects of overweight/obesity on mortality and morbidity
outcomes and the disparities, time trends, and projected future obesity health burden in …

Introduction Fatigue is a common complaint among older adults. Evidence grows that fatigue
is linked to several negative health outcomes. A general overview of fatigue and its …

Obesity is a common complex trait that elevates the risk for various diseases, including type
2 diabetes and cardiovascular disease. A combination of environmental and genetic factors …