The core axoneme structure of both the motile cilium and sperm tail has the same
ultrastructural 9+ 2 microtubular arrangement. Thus, it can be expected that genetic defects …

A finely regulated system of airway epithelial development governs the differentiation of
motile ciliated cells of the human respiratory tract, conferring the body's mucociliary …

The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

The diagnosis of primary ciliary dyskinesia is often confirmed with standard, albeit complex
and expensive, tests. In many cases, however, the diagnosis remains difficult despite the …

The Opisthokonta are a eukaryotic supergroup divided in two main lineages: animals and
related protistan taxa, and fungi and their allies [1, 2]. There is a great diversity of lifestyles …

Dysregulation of DNA methylation and mRNA alternative cleavage and polyadenylation
(APA) are both prevalent in cancer and have been studied as independent processes. We …

Mucociliary clearance is an essential lung function that facilitates the removal of inhaled
pathogens and foreign matter unidirectionally from the airway tract and is innately achieved …

Axonemal protein complexes, such as outer (ODA) and inner (IDA) dynein arms, are
responsible for the generation and regulation of flagellar and ciliary beating. Studies in …

By moving essential body fluids and molecules, motile cilia and flagella govern respiratory
mucociliary clearance, laterality determination and the transport of gametes and …

Cilia use microtubule-based intraflagellar transport (IFT) to organize intercellular signaling.
Ciliopathies are a spectrum of human diseases resulting from defects in cilia structure or …