Parkinson disease (PD) is a complex neurodegenerative disorder with both motor and
nonmotor symptoms owing to a spreading process of neuronal loss in the brain. At present …

Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains | Movement Disorders
| JAMA Neurology | JAMA Network [Skip to Navigation] Our website uses cookies to enhance …

Over the last decade, researchers have discovered that a group of apparently unrelated
neurodegenerative disorders, such as Parkinson's disease, have remarkable cellular and …

The proteasome is a large multi-subunit protease responsible for the degradation and
removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays …

Protein misfolding, aggregation and deposition are common disease mechanisms in many
neurodegenerative diseases including Parkinson's disease (PD). Accumulation of damaged …

Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss
of particular subsets of neurons. The loss of the neurons occurs during a period of many …

The investigation of pathogenic and pathophysiological mechanisms of Parkinson's disease
relies on experimental models reproducing, in the animal, the pathological and behavioural …