Background: Cancer is considered a major cause of death worldwide. The etiology of cancer
is linked to environmental and genetic inheritance causes. Approximately 90 percent of all …

Background: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal
gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of …

Extensive research over the past half a century indicates that reactive oxygen species (ROS)
play an important role in cancer. Although low levels of ROS can be beneficial, excessive …

Background In humans, many diseases are associated with the accumulation of free
radicals. Antioxidants can scavenge free radicals and minimize their impact. Therefore, the …

Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Patients with inflammatory bowel disease (IBD) are at increased risk for developing
colorectal cancer (CRC), although the overall incidence of IBD-associated CRC has been …

Epidemiological studies have clearly shown that whole-grain cereals can protect against
obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety …

Carcinogenesis is a multistep process involving mutation and the subsequent selective
clonal expansion of the mutated cell. Chemical and physical agents including those that …

The concept that the highly reactive hydroxyl radical (HO) could be generated from an
interaction between superoxide (O2−) and hydrogen peroxide (H2O2) was proposed (with …

For the last few decades, while significant improvements have been achieved in cancer
therapy, this family of diseases is still considered one of the deadliest threats to human …