Autophagy and apoptosis cascade: which is more prominent in neuronal death?
Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …
homeostasis, which are characterized by their morphology and regulated through signal …
[HTML][HTML] Parkinson's disease: alterations in iron and redox biology as a key to unlock therapeutic strategies
A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …
(PD). The literature reveals well-documented alterations consistent with established dogma …
Apoptotic cell death regulation in neurons
E Hollville, SE Romero, M Deshmukh - The FEBS journal, 2019 - Wiley Online Library
Apoptosis plays a major role in shaping the developing nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …
Neuroprotective effect of fisetin against amyloid-beta-induced cognitive/synaptic dysfunction, neuroinflammation, and neurodegeneration in adult mice
Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease and
is characterized pathologically by the accumulation of amyloid beta (Aβ) and the …
is characterized pathologically by the accumulation of amyloid beta (Aβ) and the …
Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aβ1-42-induced neuroinflammation and neurodegeneration via the NF-KB/JNK …
Abstract Amyloid-beta (Aβ 1-42) plaques and neurofibrillary tangles (NFTs) are the main
hallmarks considered to be associated with neuroinflammation in Alzheimer's disease (AD) …
hallmarks considered to be associated with neuroinflammation in Alzheimer's disease (AD) …
The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases
M Li - Apoptosis, 2021 - Springer
P53 up-regulated modulator of apoptosis (PUMA), a pro-apoptotic BCL-2 homology 3 (BH3)-
only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits …
only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits …
Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process
M Toricelli, AAR Pereira, GS Abrao… - Neural regeneration …, 2021 - journals.lww.com
Aging is a dynamic and progressive process that begins at conception and continues until
death. This process leads to a decrease in homeostasis and morphological, biochemical …
death. This process leads to a decrease in homeostasis and morphological, biochemical …
Cell death pathways: a novel therapeutic approach for neuroscientists
In the first part, the following mechanisms involved in different forms of cell death are
considered, with a view to identifying potential therapeutic targets: tumour necrosis factor …
considered, with a view to identifying potential therapeutic targets: tumour necrosis factor …
Axon injury signaling and compartmentalized injury response in glaucoma
SB Syc-Mazurek, RT Libby - Progress in retinal and eye research, 2019 - Elsevier
Axonal degeneration is an active, highly controlled process that contributes to beneficial
processes, such as developmental pruning, but also to neurodegeneration. In glaucoma …
processes, such as developmental pruning, but also to neurodegeneration. In glaucoma …
Axon degeneration gated by retrograde activation of somatic pro-apoptotic signaling
During development, sensory axons compete for limiting neurotrophic support, and local
neurotrophin insufficiency triggers caspase-dependent axon degeneration. The signaling …
neurotrophin insufficiency triggers caspase-dependent axon degeneration. The signaling …