Arguably the most defining moment in our lives is fertilization, the point at which we inherit
either an X or a Y chromosome from our father. The profoundly different journeys of male …

Sox proteins are found in all metazoans and are active in many developmental processes.
Their function as transcription factors is governed by their DNA-binding properties as much …

The mammalian Y chromosome acts as a dominant male determinant as a result of the
action of a single gene, Sry, whose role in sex determination is to initiate testis rather than …

Sex determination in mammals directs an initially bipotential gonad to differentiate into either
a testis or an ovary. This decision is triggered by the expression of the sex-determining gene …

Background: The mammalian hair represents an unparalleled model system to understand
both developmental processes and stem cell biology. The hair follicle consists of several …

The Y chromosome gene Sry encodes a transcription factor required to initiate testis
development. The related autosomal gene Sox9 is up-regulated shortly after the onset of Sry …

The molecular genetic mechanisms of cartilage construction are incompletely understood.
Zebrafish embryos homozygous for jellyfish (jef) mutations show craniofacial defects and …

Despite 12 yr since the discovery of SRY, little is known at the molecular level about how
SRY and the SRY-related protein, SOX9 [SRY-related high-mobility group (HMG) box 9] …

We have raised an antibody specifically recognizing endogenous mouse SRY protein and
used it to investigate the molecular and cellular mode of action of SRY in testis …

Recently, we demonstrated that loss of Fgf9 results in a block of testis development and a
male to female sex-reversed phenotype; however, the function of Fgf9 in sex determination …