Bruton tyrosine kinase inhibitors for multiple sclerosis
Current therapies for multiple sclerosis (MS) reduce both relapses and relapse-associated
worsening of disability, which is assumed to be mainly associated with transient infiltration of …
worsening of disability, which is assumed to be mainly associated with transient infiltration of …
Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines
MRI has improved the diagnostic work-up of multiple sclerosis, but inappropriate image
interpretation and application of MRI diagnostic criteria contribute to misdiagnosis. Some …
interpretation and application of MRI diagnostic criteria contribute to misdiagnosis. Some …
A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis
Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour
ongoing demyelination and axon degeneration, and are identifiable in vivo by their …
ongoing demyelination and axon degeneration, and are identifiable in vivo by their …
Association of chronic active multiple sclerosis lesions with disability in vivo
Importance In multiple sclerosis (MS), chronic active lesions, which previously could only be
detected at autopsy, can now be identified on susceptibility-based magnetic resonance …
detected at autopsy, can now be identified on susceptibility-based magnetic resonance …
Neuronal vulnerability and multilineage diversity in multiple sclerosis
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing–remitting disease
course at early stages, distinct lesion characteristics in cortical grey versus subcortical white …
course at early stages, distinct lesion characteristics in cortical grey versus subcortical white …
Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial
Background Tolebrutinib is an oral, CNS-penetrant, irreversible inhibitor of Bruton's tyrosine
kinase, an enzyme expressed in B lymphocytes and myeloid cells including microglia, which …
kinase, an enzyme expressed in B lymphocytes and myeloid cells including microglia, which …
Ageing and multiple sclerosis
The factor that is most relevant and strongly associated with the clinical course of multiple
sclerosis is chronological age. Very young patients exclusively have relapsing remitting …
sclerosis is chronological age. Very young patients exclusively have relapsing remitting …
Long-term evolution of multiple sclerosis iron rim lesions in 7 T MRI
A Dal-Bianco, G Grabner, C Kronnerwetter, M Weber… - Brain, 2021 - academic.oup.com
Recent data suggest that multiple sclerosis white matter lesions surrounded by a rim of iron
containing microglia, termed iron rim lesions, signify patients with more severe disease …
containing microglia, termed iron rim lesions, signify patients with more severe disease …
[HTML][HTML] Pros and cons of ultra-high-field MRI/MRS for human application
Magnetic resonance imaging and spectroscopic techniques are widely used in humans both
for clinical diagnostic applications and in basic research areas such as cognitive …
for clinical diagnostic applications and in basic research areas such as cognitive …
Regenerating CNS myelin—from mechanisms to experimental medicines
RJM Franklin, C Ffrench-Constant - Nature Reviews Neuroscience, 2017 - nature.com
Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …
and differentiation of CNS progenitors—has not changed over the past 20 years, our …