Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …

Objective. Metformin is an important component of PCOS treatment. At present, the effect of
metformin in overweight women with PCOS has not been evaluated. Therefore, we …

Acute respiratory distress syndrome (ARDS), a devastating complication of numerous
conditions, is often associated with high mortality. It is well known that endothelial cell (EC) …

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases causing
infertility in women of childbearing age. It is characterized by hyperandrogenemia (HA) …

Metformin has been in clinical use for the management of type 2 diabetes for more than 60
years and is supported by a vast database of clinical experience: this includes evidence for …

As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates
glucose levels and positively affects cardiovascular function in patients with diabetes and …

Metformin, one of the first-line of hypoglycemic drugs, has cardioprotective, anti-
inflammatory and anticancer activities, in addition to its proven hypoglycemic effects …

Aging of the vasculature, which is integral to the functioning of literally all human organs,
serves as a fundamental physiological basis for age-related alterations as well as a shared …

Objective Available evidence has shown that metformin improves insulin sensitivity and
weight management in polycystic ovary syndrome (PCOS). Nevertheless, key knowledge …

Obesity is a worrisomely escalating public health problem globally and one of the leading
causes of morbidity and mortality from noncommunicable disease. The epidemiological link …