The human thymus is a primary lymphoepithelial organ which supports the production of self‐
tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial …

Abstract The activator protein-1 (AP-1) is a dimeric transcription factor composed of proteins
belonging to the Jun (c-Jun, JunB and JunD), Fos (c-Fos, FosB, Fra1 and Fra2) and …

Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–
double negative (DN) thymocytes to generate αβ T cells in the thymus. However, how these …

Cellular senescence, an age-related process in response to damage and stress, also occurs
during normal development and adult life. The thymus is a central lymphoepithelial organ of …

Bortezomib is a potent inhibitor of proteasomes currently used to eliminate malignant
plasma cells in multiple myeloma patients. It is also effective in depleting both alloreactive …

Hassall's corpuscles are the most prominent structures in the human thymus. However,
relatively few analyses have been performed to determine their function and cellular origins …

Simple Summary Thymic carcinomas are the most aggressive thymic epithelial tumors.
While thymic carcinomas do not have a single specific cause, various aspects of their growth …

Objective Human submandibular gland (SMG) stones are associated with inflammation,
fibrosis and microcalcifications in the surrounding tissues. However, there is little information …

To understand fundamental defense mechanisms of an individual and to perceive
organization and functioning of the human immune system, it is inevitable to sum up its …

Terminal body weights (TBWs), thymus weight parameters, and thymus morphology were
retrospectively evaluated in 453 cynomolgus monkeys assigned to control groups on …