Implications of oxidative stress and cellular senescence in age‐related thymus involution
The human thymus is a primary lymphoepithelial organ which supports the production of self‐
tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial …
tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial …
Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms
Abstract The activator protein-1 (AP-1) is a dimeric transcription factor composed of proteins
belonging to the Jun (c-Jun, JunB and JunD), Fos (c-Fos, FosB, Fra1 and Fra2) and …
belonging to the Jun (c-Jun, JunB and JunD), Fos (c-Fos, FosB, Fra1 and Fra2) and …
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β− selection
Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–
double negative (DN) thymocytes to generate αβ T cells in the thymus. However, how these …
double negative (DN) thymocytes to generate αβ T cells in the thymus. However, how these …
In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution
Cellular senescence, an age-related process in response to damage and stress, also occurs
during normal development and adult life. The thymus is a central lymphoepithelial organ of …
during normal development and adult life. The thymus is a central lymphoepithelial organ of …
Proteasome inhibition with bortezomib depletes plasma cells and specific autoantibody production in primary thymic cell cultures from early-onset myasthenia gravis …
AM Gomez, N Willcox, K Vrolix, J Hummel… - The Journal of …, 2014 - journals.aai.org
Bortezomib is a potent inhibitor of proteasomes currently used to eliminate malignant
plasma cells in multiple myeloma patients. It is also effective in depleting both alloreactive …
plasma cells in multiple myeloma patients. It is also effective in depleting both alloreactive …
What do we know about the structure of human thymic Hassall's corpuscles? A histochemical, immunohistochemical, and electron microscopic study
R Mikušová, V Mešťanová, Š Polák, I Varga - Annals of Anatomy …, 2017 - Elsevier
Hassall's corpuscles are the most prominent structures in the human thymus. However,
relatively few analyses have been performed to determine their function and cellular origins …
relatively few analyses have been performed to determine their function and cellular origins …
Molecular and Functional Key Features and Oncogenic Drivers in Thymic Carcinomas
S Barachini, E Pardini, IS Burzi, G Sardo Infirri… - Cancers, 2023 - mdpi.com
Simple Summary Thymic carcinomas are the most aggressive thymic epithelial tumors.
While thymic carcinomas do not have a single specific cause, various aspects of their growth …
While thymic carcinomas do not have a single specific cause, various aspects of their growth …
Microcalcifications in stone-obstructed human submandibular gland are associated with apoptosis and cell proliferation
I Lau, A Potluri, CL Ibeh, RS Redman, E Paal… - Archives of oral …, 2017 - Elsevier
Objective Human submandibular gland (SMG) stones are associated with inflammation,
fibrosis and microcalcifications in the surrounding tissues. However, there is little information …
fibrosis and microcalcifications in the surrounding tissues. However, there is little information …
Morphological view on the evolution of the immunity and lymphoid organs of vertebrates, focused on thymus
V Mešťanová, I Varga - Biologia, 2016 - degruyter.com
To understand fundamental defense mechanisms of an individual and to perceive
organization and functioning of the human immune system, it is inevitable to sum up its …
organization and functioning of the human immune system, it is inevitable to sum up its …
Maturity-related Variability of the Thymus in Cynomolgus Monkeys (Macaca fascicularis)
PW Snyder, NE Everds, WA Craven… - Toxicologic …, 2016 - journals.sagepub.com
Terminal body weights (TBWs), thymus weight parameters, and thymus morphology were
retrospectively evaluated in 453 cynomolgus monkeys assigned to control groups on …
retrospectively evaluated in 453 cynomolgus monkeys assigned to control groups on …