Endoplasmic reticulum–mitochondria signaling in neurons and neurodegenerative diseases
A Markovinovic, J Greig… - Journal of Cell …, 2022 - journals.biologists.com
Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …
Pleiotropic mitochondria: the influence of mitochondria on neuronal development and disease
Mitochondria play many important biological roles, including ATP production, lipid
biogenesis, ROS regulation, and calcium clearance. In neurons, the mitochondrion is an …
biogenesis, ROS regulation, and calcium clearance. In neurons, the mitochondrion is an …
Cryptic exon detection and transcriptomic changes revealed in single-nuclei RNA sequencing of C9ORF72 patients spanning the ALS-FTD spectrum
The C9ORF72-linked diseases amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) are characterized by the nuclear depletion and cytoplasmic accumulation of …
dementia (FTD) are characterized by the nuclear depletion and cytoplasmic accumulation of …
Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration
Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are morpho-functional
units, formed at the loci of close apposition of the ER-forming endomembrane and outer …
units, formed at the loci of close apposition of the ER-forming endomembrane and outer …
Structure and function of mitochondria‐associated endoplasmic reticulum membranes (MAMs) and their role in cardiovascular diseases
Y Luan, Y Luan, RX Yuan, Q Feng… - … Medicine and Cellular …, 2021 - Wiley Online Library
Abnormal function of suborganelles such as mitochondria and endoplasmic reticulum often
leads to abnormal function of cardiomyocytes or vascular endothelial cells and …
leads to abnormal function of cardiomyocytes or vascular endothelial cells and …
Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases
The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular
organelles with vital roles in the regulation of cell signaling and function. While the ER …
organelles with vital roles in the regulation of cell signaling and function. While the ER …
Axonal endoplasmic reticulum dynamics and its roles in neurodegeneration
The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …
VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity
O Bapat, T Purimetla, S Kruessel, M Shah… - Nature …, 2024 - nature.com
Synapses are pivotal sites of plasticity and memory formation. Consequently, synapses are
energy consumption hotspots susceptible to dysfunction when their energy supplies are …
energy consumption hotspots susceptible to dysfunction when their energy supplies are …
The ER-mitochondria interface, where Ca2+ and cell death meet
I de Ridder, M Kerkhofs, FO Lemos, J Loncke… - Cell calcium, 2023 - Elsevier
Endoplasmic reticulum (ER)-mitochondria contact sites are crucial to allow Ca 2+ flux
between them and a plethora of proteins participate in tethering both organelles together …
between them and a plethora of proteins participate in tethering both organelles together …
Disruption of ER‐mitochondria tethering and signalling in C9orf72‐associated amyotrophic lateral sclerosis and frontotemporal dementia
P Gomez‐Suaga, GM Mórotz, A Markovinovic… - Aging …, 2022 - Wiley Online Library
Hexanucleotide repeat expansions in C9orf72 are the most common cause of familial
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mechanisms by …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mechanisms by …