Growth hormone deficiency: health and longevity

MH Aguiar-Oliveira, A Bartke - Endocrine reviews, 2019 - academic.oup.com
The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …

Mechanisms in endocrinology: the multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene …

MH Aguiar-Oliveira, AHO Souza… - European journal of …, 2017 - academic.oup.com
Twenty years ago, we described kindred of 105 individuals with isolated GH deficiency
(IGHD) in Itabaianinha County, in northeast Brazil, carrying a homozygous mutation in the …

Common and uncommon mouse models of growth hormone deficiency

EO List, R Basu, DE Berryman, S Duran-Ortiz… - Endocrine …, 2024 - academic.oup.com
Mouse models of growth hormone deficiency (GHD) have provided important tools for
uncovering the various actions of GH. Nearly 100 years of research using these mouse lines …

Should patients with adult GH deficiency receive GH replacement?

JOL Jørgensen, G Johannsson… - European Journal of …, 2022 - academic.oup.com
Pituitary human growth hormone (GH) was isolated 75 years ago (1), and its protein
anabolic and fat catabolic effects were studied soon thereafter (2, 3, 4). Another significant …

Growth hormone therapy in adults with growth hormone deficiency: a critical assessment of the literature

X He, AL Barkan - Pituitary, 2020 - Springer
Purpose Growth hormone (GH) therapy has been studied as treatment for clinical
manifestations of adult-onset growth hormone deficiency (AO-GHD), including …

Vasculometabolic effects in patients with congenital growth hormone deficiency with and without GH replacement therapy during adulthood

IP Biscotto, VA Costa Hong, RL Batista, BB Mendonca… - Pituitary, 2021 - Springer
Purpose To evaluated the metabolic profiles and vascular properties in congenital growth
hormone (GH) deficiency (GHD) and its replacement in adults. Patients and methods Cross …

Receptor transduction pathways mediating hormone action

B Kublaoui, MA Levine - Sperling Pediatric Endocrinology, 2021 - Elsevier
This chapter describes basic principles of receptor action including definitions of agonists,
antagonists, inverse agonists, including basic pharmacology of receptor binding, activation …

[PDF][PDF] Cтан серцево-судинної системи та ліпідний спектр при соматотропній недостатності у молодих дорослих із маніфестацією в дитячому віці (огляд …

ОВ Большова, ОА Вишневська, ОЯ Самсон - 2015 - ir.nuozu.edu.ua
Проведено аналіз наукової літератури стосовно особливостей клінічного перебігу
дефіциту гормона росту (ДГР), що маніфестував у дитячому віці, у молодих дорослих …

Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment

E Hallengren, P Almgren, M Rosvall, G Östling… - BMC Cardiovascular …, 2017 - Springer
Background Growth hormone (GH) has been linked to cardiovascular disease but the exact
mechanism of this association is still unclear. We here test if the fasting levels of GH are …

Escore de cálcio coronário na estratificação do risco cardiovascular de portadores de HIV/AIDS em tratamento

ÚMMC Burgos - 2019 - ri.ufs.br
Escore de Cálcio na Estratificação do Risco Cardiovascular em Portadores de HIV/AIDS em
tratamento, Ursula Maria Moreira Costa Burgos, Aracaju, 2019. Introdução. Nos dias atuais …