Recent advances in fluorescence-based microscopy techniques, such as single molecule
fluorescence, Förster resonance energy transfer (FRET), fluorescence intensity fluctuations …

Fundamental properties of light unavoidably impose features on images collected using
fluorescence microscopes. Accounting for these features is often critical in quantitatively …

Polycomb repressive complexes (PRCs) play a key role in gene repression and are
indispensable for proper development. Canonical PRC1 forms condensates in vitro and in …

Unraveling the concentration-dependent spatiotemporal organization of receptors in the
plasma membrane is crucial to understand cell signal initiation. A paradigm of this process is …

Efforts to advance RNA aptamers as a new therapeutic modality have been limited by their
susceptibility to degradation and immunogenicity. In a previous study, we demonstrated …

Collagen has been proposed to bind to a unique epitope in dimeric glycoprotein VI (GPVI)
and the number of GPVI dimers has been reported to increase upon platelet activation …

We use single-molecule techniques to characterize the dynamics of prokaryotic DNA repair
by non-homologous end-joining (NHEJ), a system comprised only of the dimeric Ku and …

CLEC-2 is a target for a new class of antiplatelet agent. Clustering of CLEC-2 leads to
phosphorylation of a cytosolic YxxL and binding of the tandem SH2 domains in Syk …

Life's fundamental processes involve multiple molecules operating in close proximity within
cells. To probe the molecular composition of such small (diffraction-limited) regions …

Determining the label to target ratio, also known as the degree of labeling (DOL), is crucial
for quantitative fluorescence microscopy and a high DOL with minimal unspecific labeling is …