Colorectal cancer (CRC) accounts for over 8% of all deaths annually worldwide. Between 2
and 5% of all CRCs occur due to inherited syndromes, including Lynch syndrome, familial …

Purpose Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC)
syndrome, with an estimated prevalence of 2% to 3% of CRC. A prevalence study is needed …

ContextThe selection of individuals for hereditary nonpolyposis colorectal cancer (HNPCC)
genetic testing is challenging. Recently, the National Cancer Institute outlined a new set of …

ContextIdentifying families at high risk for the Lynch syndrome (ie, hereditary nonpolyposis
colorectal cancer) is critical for both genetic counseling and cancer prevention. Current …

BACKGROUND AND AIMS In this study, we prospectively examined the clinical significance
of the microsatellite instability (MSI) phenotype in sporadic colorectal cancer, and …

Context.—Cancer immunotherapy provides unprecedented rates of durable clinical benefit
to late-stage cancer patients across many tumor types, but there remains a critical need for …

A comprehensive analysis of somatic and germline mutations related to DNA mismatch–
repair (MMR) genes can clarify the prevalence and mechanism of inactivation in colorectal …

Basic studies of DNA replication and repair have provided surprising and pivotal insights
into a novel pathway of tumorigenesis. Defects in the DNA mismatch repair process …

Background The aim of the present study was to identify the clinicopathological and
molecular biological characteristics of early-onset colorectal cancers. Methods The …

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer
predisposition syndrome caused by germ-line mutations in DNA mismatch repair genes. It is …