PSMD9 promotes the malignant progression of hepatocellular carcinoma by interacting with c-Cbl to activate EGFR signaling and recycling
Y Su, L Meng, C Ge, Y Liu, C Zhang, Y Yang… - Journal of Experimental …, 2024 - Springer
Background Mounting evidences shows that the ubiquitin‒proteasome pathway plays a
pivotal role in tumor progression. The expression of 26S proteasome non-ATPase regulatory …
pivotal role in tumor progression. The expression of 26S proteasome non-ATPase regulatory …
p97/VCP promotes the recycling of endocytic cargo
M Kawan, M Körner, A Schlosser… - Molecular Biology of …, 2023 - Am Soc Cell Biol
The endocytic pathway is of central importance for eukaryotic cells, as it enables uptake of
extracellular materials, membrane protein quality control and recycling, as well as …
extracellular materials, membrane protein quality control and recycling, as well as …
[HTML][HTML] EGFR endocytosis: more than meets the eye
A Sapmaz, AE Erson-Bensan - Oncotarget, 2023 - ncbi.nlm.nih.gov
Behind the scenes of signaling cascades initiated by activated receptors, endocytosis
determines the fate of internalized proteins through degradation in lysosomes or recycling …
determines the fate of internalized proteins through degradation in lysosomes or recycling …
Separable Roles for Neur and Ubiquitin in Delta Signalling in the Drosophila CNS Lineages
K Kalodimou, M Stapountzi, N Vüllings, E Seib, T Klein… - Cells, 2023 - mdpi.com
The execution of a Notch signal at the plasma membrane relies on the mechanical force
exerted onto Notch by its ligand. It has been appreciated that the DSL ligands need to …
exerted onto Notch by its ligand. It has been appreciated that the DSL ligands need to …
E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP‐1 Proteasomal Degradation
W Liu, Y Wang, S Liu, X Zhang, X Cao… - Advanced …, 2024 - Wiley Online Library
As a highly organized system, endo‐lysosomes play a crucial role in maintaining immune
homeostasis. However, the mechanisms involved in regulating endo‐lysosome progression …
homeostasis. However, the mechanisms involved in regulating endo‐lysosome progression …
Common lizard primary oviduct cell culture: A model system for the genetic and cellular basis of oviparity and viviparity
Reproduction by egg-laying (oviparity) or live-bearing (viviparity) is a genetically determined
trait fundamental to the biology of amniotes. Squamates are an emerging model for the …
trait fundamental to the biology of amniotes. Squamates are an emerging model for the …
An internal linker and pH biosensing by phosphatidylinositol 5-phosphate regulate the function of the ESCRT-0 component TOM1
W Xiong, TG Roach, N Ball, M Corluka, J Beyer… - Structure, 2024 - cell.com
Summary Target of Myb1 (TOM1) facilitates the transport of endosomal ubiquitinated
proteins destined for lysosomal degradation; however, the mechanisms regulating TOM1 …
proteins destined for lysosomal degradation; however, the mechanisms regulating TOM1 …