Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good

K Krebs, L Milani - Human genomics, 2019 - Springer
The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single
genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce …

Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers

HM Dunnenberger, KR Crews… - Annual review of …, 2015 - annualreviews.org
Although the field of pharmacogenetics has existed for decades, practioners have been slow
to implement pharmacogenetic testing in clinical care. Numerous publications describe the …

Learning from longitudinal data in electronic health record and genetic data to improve cardiovascular event prediction

J Zhao, QP Feng, P Wu, RA Lupu, RA Wilke… - Scientific reports, 2019 - nature.com
Current approaches to predicting a cardiovascular disease (CVD) event rely on
conventional risk factors and cross-sectional data. In this study, we applied machine …

[HTML][HTML] Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development …

KE Caudle, TE Klein, JM Hoffman, DJ Müller… - Current drug …, 2014 - ncbi.nlm.nih.gov
Abstract The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes
genotype-based drug guidelines to help clinicians understand how available genetic test …

Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing

SL Van Driest, Y Shi, EA Bowton… - Clinical …, 2014 - Wiley Online Library
Since September 2010, more than 10,000 patients have undergone preemptive, panel‐
based pharmacogenomic testing through the Vanderbilt Pharmacogenomic Resource for …

[HTML][HTML] Secondary use of clinical data: the Vanderbilt approach

I Danciu, JD Cowan, M Basford, X Wang, A Saip… - Journal of biomedical …, 2014 - Elsevier
The last decade has seen an exponential growth in the quantity of clinical data collected
nationwide, triggering an increase in opportunities to reuse the data for biomedical research …

Pharmacogenomics in practice: A review and implementation guide

D Kabbani, R Akika, A Wahid, AK Daly… - Frontiers in …, 2023 - frontiersin.org
Considerable efforts have been exerted to implement Pharmacogenomics (PGx), the study
of interindividual variations in DNA sequence related to drug response, into routine clinical …

Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality

H Xu, MC Aldrich, Q Chen, H Liu… - Journal of the …, 2015 - academic.oup.com
Objectives Drug repurposing, which finds new indications for existing drugs, has received
great attention recently. The goal of our work is to assess the feasibility of using electronic …

Design and anticipated outcomes of the eMERGE‐PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems

LJ Rasmussen‐Torvik, SC Stallings… - Clinical …, 2014 - Wiley Online Library
We describe here the design and initial implementation of the eMERGE‐PGx project.
eMERGE‐PGx, a partnership of the Electronic Medical Records and Genomics Network and …

Genophenotypic factors and pharmacogenomics in adverse drug reactions

R Cacabelos, V Naidoo, L Corzo, N Cacabelos… - International journal of …, 2021 - mdpi.com
Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …