Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good
The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single
genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce …
genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce …
Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers
HM Dunnenberger, KR Crews… - Annual review of …, 2015 - annualreviews.org
Although the field of pharmacogenetics has existed for decades, practioners have been slow
to implement pharmacogenetic testing in clinical care. Numerous publications describe the …
to implement pharmacogenetic testing in clinical care. Numerous publications describe the …
Learning from longitudinal data in electronic health record and genetic data to improve cardiovascular event prediction
Current approaches to predicting a cardiovascular disease (CVD) event rely on
conventional risk factors and cross-sectional data. In this study, we applied machine …
conventional risk factors and cross-sectional data. In this study, we applied machine …
[HTML][HTML] Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development …
Abstract The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes
genotype-based drug guidelines to help clinicians understand how available genetic test …
genotype-based drug guidelines to help clinicians understand how available genetic test …
Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing
SL Van Driest, Y Shi, EA Bowton… - Clinical …, 2014 - Wiley Online Library
Since September 2010, more than 10,000 patients have undergone preemptive, panel‐
based pharmacogenomic testing through the Vanderbilt Pharmacogenomic Resource for …
based pharmacogenomic testing through the Vanderbilt Pharmacogenomic Resource for …
[HTML][HTML] Secondary use of clinical data: the Vanderbilt approach
The last decade has seen an exponential growth in the quantity of clinical data collected
nationwide, triggering an increase in opportunities to reuse the data for biomedical research …
nationwide, triggering an increase in opportunities to reuse the data for biomedical research …
Pharmacogenomics in practice: A review and implementation guide
Considerable efforts have been exerted to implement Pharmacogenomics (PGx), the study
of interindividual variations in DNA sequence related to drug response, into routine clinical …
of interindividual variations in DNA sequence related to drug response, into routine clinical …
Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality
Objectives Drug repurposing, which finds new indications for existing drugs, has received
great attention recently. The goal of our work is to assess the feasibility of using electronic …
great attention recently. The goal of our work is to assess the feasibility of using electronic …
Design and anticipated outcomes of the eMERGE‐PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems
LJ Rasmussen‐Torvik, SC Stallings… - Clinical …, 2014 - Wiley Online Library
We describe here the design and initial implementation of the eMERGE‐PGx project.
eMERGE‐PGx, a partnership of the Electronic Medical Records and Genomics Network and …
eMERGE‐PGx, a partnership of the Electronic Medical Records and Genomics Network and …
Genophenotypic factors and pharmacogenomics in adverse drug reactions
R Cacabelos, V Naidoo, L Corzo, N Cacabelos… - International journal of …, 2021 - mdpi.com
Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …
illness in developed countries. ADRs show differential features depending upon genotype …