Orai (Orai1, Orai2, and Orai3) proteins form a family of highly Ca2+-selective plasma
membrane channels that are regulated by stromal-interacting molecules (STIM1 and …

Caveolae are membrane microdomains described in many cell types involved in
endocytocis, transcytosis, cell signaling, mechanotransduction, and aging. They are found at …

Emerging studies have reported the mechanosensitive Piezo1 (piezo type
mechanosensitive ion channel component 1) plays essential roles in regulating the vascular …

Background High-altitude cerebral edema (HACE) is a serious and potentially fatal brain
injury that is caused by acute hypobaric hypoxia (HH) exposure. Vasogenic edema is the …

Previous studies have demonstrated that besides the classic canonical transient receptor
potential channel family, Orai family and stromal interaction molecule 1 (STIM1) might also …

The pulmonary arteries are exquisitely responsive to oxygen changes. They rapidly and
proportionally contract as arterial PO2 decrease, and they relax as arterial PO2 is re …

Previous studies have reported the beneficial role of Aloperine (ALO), an active vasodilator
purified from the seeds and leaves of the herbal plant Sophora alopecuroides L., on …

Significance: Peroxisome proliferator-activated receptor-gamma (PPARγ) maintains
pulmonary vascular health through coordination of antioxidant defense systems …

Our early experiments confirmed that rosiglitazone (RSG), a peroxisome proliferator-
activated receptor γ (PPARγ) agonist, had therapeutic potential for the treatment of diffuse …

The ubiquitin-proteasome system is considered to be the key regulator of protein
degradation. Bortezomib (BTZ) is the first proteasome inhibitor approved by the US Food …