Arrival of the novel SARS-CoV-2 has launched a worldwide effort to identify both pre-
approved and novel therapeutics targeting the viral proteome, highlighting the urgent need …

Automated data collection for macromolecular crystallography - ScienceDirect Skip to main
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Small Angle X-ray Scattering (SAXS) is a powerful tool in the study of biological
macromolecules providing information about the shape, conformation, assembly and folding …

The SIBYLS beamline (12.3. 1) of the Advanced Light Source at Lawrence Berkeley
National Laboratory, supported by the US Department of Energy and the National Institutes …

FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that
the H2A-H2B binding activity that is central to FACT function resides in short acidic regions …

EDNA is a framework for developing plugin-based applications especially for online data
analysis in the X-ray experiments field. This article describes the features provided by the …

Considerable effort is dedicated to evaluating macromolecular crystals at synchrotron
sources, even for well established and robust systems. Much of this work is repetitive, and …

Many bacteria use large modular enzymes for the synthesis of polyketide and peptide
natural products. These multidomain enzymes contain integrated carrier domains that …

Cytochrome P450 (CYP) 24A1 catalyzes the side-chain oxidation of the hormonal form of
vitamin D. Expression of CYP24A1 is up-regulated to attenuate vitamin D signaling …

MicroRNAs (miRNAs) direct post-transcriptional regulation of human genes by guiding
Argonaute proteins to complementary sites in messenger RNAs (mRNAs) targeted for …