The extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase
(MAPK) signalling pathway regulates many cellular functions, including proliferation …

RAF family kinases were among the first oncoproteins to be described more than 30 years
ago. They primarily act as signalling relays downstream of RAS, and their close ties to …

The gut microbiota affects nutrient acquisition and energy regulation of the host, and can
influence the development of obesity, insulin resistance, and diabetes. During feeding, gut …

First identified in the early 1980s as retroviral oncogenes, the Raf proteins have been the
objects of intense research. The discoveries 10 years later that the Raf family members (Raf …

Brown adipocytes are a primary site of energy expenditure and reside not only in classical
brown adipose tissue but can also be found in white adipose tissue. Here we show that …

Signaling cascades that control adipogenesis are essential in the regulation of body weight
and obesity. The adaptor p62 controls pathways that modulate cell differentiation. We report …

Scaffold proteins contribute to the spatiotemporal control of MAPK signaling and KSR1 is an
ERK cascade scaffold that localizes to the plasma membrane in response to growth factor …

Hearing loss is a major disability in everyday life and therapeutic interventions to protect
hearing would benefit a large portion of the world population. Here we found that mice …

Increased nutrient intake leads to excessive adipose tissue accumulation, obesity, and the
development of associated metabolic disorders. How the intestine signals to adipose tissue …

Kinase suppressors of Ras 1 and 2 (KSR1 and KSR2) function as molecular scaffolds to
potently regulate the MAP kinases ERK1/2 and affect multiple cell fates. Here we show that …