Chronic exposure to environmental pollutants is a major contributor to the development and
progression of obstructive airway diseases, including asthma and COPD. Understanding the …

Particulate matter (PM) is the principal component of air pollution. PM includes a range of
particle sizes, such as coarse, fine, and ultrafine particles. Particles that are< 100 nm in …

Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …

Background Silica continues to represent an intriguing topic of fundamental and applied
research across various scientific fields, from geology to physics, chemistry, cell biology, and …

Silicon dioxide (SiO2) is a mineral compound present in the Earth's crust in two mineral
forms: crystalline and amorphous. Based on epidemiological and/or biological evidence, the …

Background Genotoxicity is an important toxicological endpoint due to the link to diseases
such as cancer. Therefore, an increased understanding regarding genotoxicity and …

Our respiratory system is exposed to toxicants and pathogens from both sides: the airways
and the vasculature. While tracheal, bronchial and alveolar epithelial cells form a natural …

Background Respirable crystalline silica causes lung carcinomas and many thousand future
cancer cases are expected in eg Europe. Critical questions are how silica causes …

Abstract Silicon dioxide nanoparticles (SiO2NPs) are widely applied in industry, chemical,
and cosmetics. SiO2NPs is known to induce pulmonary toxicity. In this study, we investigated …

The pharmacological potential of nanotechnology, especially in drug delivery and
bioengineering, has developed rapidly in recent decades. Ion channels, which are easily …