Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Signal transduction by the Toll-like receptors (TLRs) is central to host defence against many
pathogenic microorganisms and also underlies a large burden of human disease. Thus, the …

Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

The development of culture-independent techniques for microbiological analysis has
uncovered the previously unappreciated complexity of the bacterial microbiome at various …

Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including
bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which …

The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

Innate immune receptors have a key role in immune surveillance by sensing
microorganisms and initiating protective immune responses. However, the innate immune …

Recent years have witnessed an explosion of interest in the innate immune system.
Questions about how the innate immune system senses infection and empowers a …

Signalling by Toll-like receptors (TLRs) involves five adaptor proteins known as MyD88,
MAL, TRIF, TRAM and SARM. Recent insights have revealed additional functions for MyD88 …