Sticky Business: Correlating Oligomeric Features of Class B Scavenger Receptors to Lipid Transport

EA Tillison, D Sahoo - Current Atherosclerosis Reports, 2024 - Springer
This review highlights two emerging hypotheses regarding the function of scavenger
receptor oligomerization. The first is a hydrophobic channel created by self-association of …

Diffusion and Viscosity in Mixed Protein Solutions

S Wozniak, M Feig - The Journal of Physical Chemistry B, 2024 - ACS Publications
The viscosity and diffusion properties of crowded protein systems were investigated with
molecular dynamics simulations of SH3 mixtures with different crowders, and results were …

BhrPETase catalyzed polyethylene terephthalate depolymerization: A quantum mechanics/molecular mechanics approach

N Wang, Y Li, M Zheng, W Dong, Q Zhang… - Journal of Hazardous …, 2024 - Elsevier
Polyethylene terephthalate (PET) is a widely used material in our daily life, particularly in
areas such as packaging, fibers, and engineering plastics. However, PET waste can …

GRACE: Generative Redesign in Artificial Computational Enzymology

RE Hu, CH Yu, IS Ng - ACS Synthetic Biology, 2024 - ACS Publications
Designing de novo enzymes is complex and challenging, especially to maintain the activity.
This research focused on motif design to identify the crucial domain in the enzyme and …

BEMM-GEN: A Toolkit for Generating a Biomolecular Environment-Mimicking Model for Molecular Dynamics Simulation

T Yasuda, R Morita, Y Shigeta… - Journal of Chemical …, 2024 - ACS Publications
Understanding the influence of the cellular environment on protein conformations is crucial
for elucidating protein functions within living cells. In studies using molecular dynamics (MD) …

All-Atom Membrane Builder via Multiscale Simulation

S Kim - Journal of Chemical Information and Modeling, 2024 - ACS Publications
I present an automated and flexible tool designed for constructing bilayer membranes at all-
atom (AA) resolution. The builder initiates the construction and equilibration of bilayer …

Exploring Latent Space for Generating Peptide Analogs Using Protein Language Models

PY Liang, X Huang, T Duran, AJ Wiemer… - arXiv preprint arXiv …, 2024 - arxiv.org
Generating peptides with desired properties is crucial for drug discovery and biotechnology.
Traditional sequence-based and structure-based methods often require extensive datasets …