Therapeutic potential of melatonin related to its role as an autophagy regulator: A review

JA Boga, B Caballero, Y Potes… - Journal of pineal …, 2019 - Wiley Online Library
There are several pathologies, syndromes, and physiological processes in which autophagy
is involved. This process of self‐digestion that cells trigger as a survival mechanism is …

Role of melatonin in the regulation of autophagy and mitophagy: a review

A Coto-Montes, JA Boga, S Rosales-Corral… - Molecular and cellular …, 2012 - Elsevier
Oxidative stress plays an essential role in triggering many cellular processes including
programmed cell death. Proving a relationship between apoptosis and reactive oxygen …

Melatonin ameliorates excessive PINK1/Parkin-mediated mitophagy by enhancing SIRT1 expression in granulosa cells of PCOS

S Yi, B Zheng, Y Zhu, Y Cai, H Sun… - American Journal of …, 2020 - journals.physiology.org
Mitochondrial injury in granulosa cells is associated with the pathogenesis of polycystic
ovary syndrome (PCOS). However, the protective effects of melatonin against mitochondrial …

[HTML][HTML] Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: Implication of an antioxidation-independent …

M Shen, Y Cao, Y Jiang, Y Wei, H Liu - Redox biology, 2018 - Elsevier
Oxidative stress has been described as a prime driver of granulosa cell (GCs) death during
follicular atresia. Increasing evidence suggests potential roles of melatonin in protecting …

Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation

LY Su, H Li, L Lv, YM Feng, GD Li, R Luo, HJ Zhou… - Autophagy, 2015 - Taylor & Francis
Autophagy is involved in the pathogenesis of neurodegenerative diseases including
Parkinson disease (PD). However, little is known about the regulation of autophagy in …

Beneficial actions of melatonin in the management of viral infections: a new use for this “molecular handyman”?

JA Boga, A Coto‐Montes… - Reviews in medical …, 2012 - Wiley Online Library
SUMMARY Melatonin (N‐acetyl‐5‐methoxytryptamine) is a multifunctional signaling
molecule that has a variety of important functions. Numerous clinical trials have examined …

Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by …

YM Feng, YF Jia, LY Su, D Wang, L Lv, L Xu, YG Yao - Autophagy, 2013 - Taylor & Francis
Drug addiction is a chronic brain disease that is a serious social problem and causes
enormous financial burden. Because mitochondrial abnormalities have been associated …

p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence

Y Potes, JC Bermejo-Millo, C Mendes… - Cell Death & …, 2024 - nature.com
During aging, muscle regenerative capacities decline, which is concomitant with the loss of
satellite cells that enter in a state of irreversible senescence. However, what mechanisms …

IGFBP 3 and MAPK/ERK signaling mediates melatonin‐induced antitumor activity in prostate cancer

JC Mayo, D Hevia, I Quiros‐Gonzalez… - Journal of Pineal …, 2017 - Wiley Online Library
Abstract Treatment of prostate cancer (PC a), a leading cause of cancer among males, lacks
successful strategies especially in advanced, hormone‐refractory stages. Some clinical …

Melatonin as an endogenous regulator of diseases: the role of autophagy

A Roohbakhsh, A Shamsizadeh, AW Hayes… - Pharmacological …, 2018 - Elsevier
Melatonin has long been known for its apparent effects on sleep and circadian rhythm. It
may participate as a possible therapeutic agent in neurodegenerative, cardiovascular, and …