Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Tumors that express detectable levels of the product of the ESR1 gene (estrogen receptor-α;
ERα) represent the single largest molecular subtype of breast cancer. More women …

To provide a detailed analysis of the molecular components and underlying mechanisms
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based …

Understanding diseases requires identifying the differences between healthy and affected
tissues. Gene expression data have revolutionized the study of diseases by making it …

Many studies have been carried out for early diagnosis of complex diseases by finding
accurate and robust biomarkers specific to respective diseases. In particular, recent rapid …

How breast cancer cells respond to the stress of endocrine therapies determines whether
they will acquire a resistant phenotype or execute a cell-death pathway. After a survival …

Cancers of the breast and other tissues arise from aberrant decision-making by cells
regarding their survival or death, proliferation or quiescence, damage repair or bypass …

Motivation: Cancer progression and development are initiated by aberrations in various
molecular networks through coordinated changes across multiple genes and pathways. It is …

Background: Not all breast cancer patients benefit from neoadjuvant or adjuvant therapy,
resulting in considerable undertreatment or overtreatment. New insights into the role of …

Globally with over 10 million deaths per year, cancer is the most transversal disease across
countries, cultures, and ethnicities, affecting both developed and developing regions …