Gene therapy is the process of introducing foreign genomic materials into host cells to elicit
a therapeutic benefit. Although initially the main focus of gene therapy was on special …

Gene delivery using nonviral approaches has been extensively studied as a basic tool for
intracellular gene transfer and gene therapy. In the past, the primary focus has been on …

(51) Int. Cl. The same apparatus or anotherapparatus is used to administer A6M
37/00(2006.01) a therapeutic agent based at least in part on collected biom A6 …

Ultrasound exposure (USE) in the presence of microbubbles (MCB)(eg contrast agents used
to enhance ultrasound imaging) increases plasmid transfection efficiency in vitro by several …

Liposome-based drug and gene delivery systems have potential for significant roles in a
variety of therapeutic applications. Recently, liposomes have been used to entrap gas and …

Ultrasound is a very effective modality for drug delivery and gene therapy because energy
that is non-invasively transmitted through the skin can be focused deeply into the human …

Ultrasound (US)/microbubble-mediated gene delivery is a technology with many potential
advantages suited to clinical application. Previous studies have demonstrated transfection …

The concept of gene therapy includes not only the addition of normal genes to genetically
deficient cells, but also the use of transgenes encoding several peptides that function to …

Purpose To test whether plasmid-binding cationic microbubbles (MBs) enhance ultrasound-
mediated gene delivery efficiency relative to control neutral MBs in cell culture and in vivo …

The development of microbubbles as ultrasound contrast agents (USCA) has opened the
way for new and extended applications of ultrasound in clinical practise as well as offering …