Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …

Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …

Tie-1 and Tie-2 tyrosine kinase receptors are expressed specifically on vascular endothelial
cells and on a certain subtype of macrophages implicated in angiogenesis, thus, they have …

Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve
overall survival of patients with glioblastoma (GBM). We previously showed that angiopoietin …

Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously
demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the …

Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls
embryonic development and is also involved in numerous life-threatening human diseases …

The angiopoietin/Tie (ANG/Tie) receptor system controls developmental and tumor
angiogenesis, inflammatory vascular remodeling, and vessel leakage. ANG1 is a Tie2 …

Endothelial cell migration is essential to angiogenesis. This motile process is directionally
regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves …

The correct development of blood vessels is crucial for all aspects of tissue growth and
physiology in vertebrates. The formation of an elaborate hierarchically branched network of …

Abstract The angiopoietins Ang-1 and Ang-2 have been identified as ligands with opposing
functions of the receptor tyrosine kinase Tie-2 regulating endothelial cell survival and …