Radiation-induced alterations in cellular tissue homeostasis triggered by various molecular
responses at the level of inter-and intracellular signaling processes cause both acute and …

Enormous advances in the development of skin substitutes have occurred in the past 3
decades. Major obstacles yet to be overcome in the quest for an optimal skin substitute …

Purpose: The lung is the major dose-limiting organ for radiotherapy of cancer in the thoracic
region. The pathogenesis of radiation-induced lung injury at the molecular level is still …

Stress-induced premature senescence (SIPS) is induced 3 days after exposure of human
diploid fibroblasts to subcytotoxic oxidative stress with H 2 O 2, with appearance of several …

Fibrosis is characterized by extracellular matrix deposition, of which collagen type I is the
major constituent. The progressive accumulation of connective tissue resulted in destruction …

Chronic graft-versus-host disease (cGvHD) and systemic sclerosis (scleroderma [SSc])
share clinical characteristics, including skin and internal organ fibrosis. Fibrosis, regardless …

Purpose: To determine whether curcumin ameliorates acute and chronic radiation skin
toxicity and to examine the expression of inflammatory cytokines (interleukin [IL]-1, IL-6, IL …

Purpose: Recent data from the literature and the experimental work of the authors clearly
indicate that TGF-beta 1 is a key modulator of cellular events, for example, induction of …

Objective To evaluate the factors involved in bone remodeling and wound healing that may
be altered by radiation therapy. Design A prospective, controlled study of biochemical …

Cells with osteogenic potential can be found in a variety of tissues. Here we show that
circulating osteogenic precursor (COP) cells, a bone marrow-derived type I …