Whereas a variety of pre-exercise activities have been incorporated as part of a “warm-up”
prior to work, combat, and athletic activities for millennia, the inclusion of static stretching …

In contrast to isometric and shortening contractions, many observations made on actively
lengthening muscles cannot be readily explained with the sliding filament and cross-bridge …

For the past 60 years, muscle contraction had been thought to be governed exclusively by
the contractile filaments, actin, and myosin. This thinking explained most observations for …

Muscle contraction and force regulation in skeletal muscle have been thought to occur
exclusively through the relative sliding of and the interaction between the contractile …

Eccentric muscle properties are not well characterized by the current paradigm of the
molecular mechanism of contraction: the cross-bridge theory. Findings of force contributions …

Despite an age-related loss of voluntary isometric and concentric strength, muscle strength
is well maintained during lengthening muscle actions (ie, eccentric strength) in old age …

The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and
regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point …

The sliding filament theory of muscle contraction is widely accepted as the means by which
muscles generate force during activation. Within the constraints of this theory, isometric …

It is well acknowledged that muscles that are elongated while activated (ie, eccentric muscle
action) are stronger and require less energy (per unit of force) than muscles that are …

We propose and examine a three filament model of skeletal muscle force generation,
thereby extending classical cross-bridge models by involving titin-actin interaction upon …