Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Important flavonoids and their role as a therapeutic agent

A Ullah, S Munir, SL Badshah, N Khan, L Ghani… - Molecules, 2020 - mdpi.com
Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and
leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of …

Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin …

C Mouffouk, S Mouffouk, S Mouffouk… - European journal of …, 2021 - Elsevier
The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The …

[HTML][HTML] Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential

SA Rajput, X Wang, HC Yan - Biomedicine & pharmacotherapy, 2021 - Elsevier
Flavonoids are natural plant-derived dietary bioactive compounds having a substantial
impact on human health. Morin hydrate is a bioflavonoid mainly obtained from fruits, stem …

[HTML][HTML] Umbelliferone prevents isoproterenol-induced myocardial injury by upregulating Nrf2/HO-1 signaling, and attenuating oxidative stress, inflammation, and cell …

OY Althunibat, MS Abduh, MH Abukhalil… - Biomedicine & …, 2022 - Elsevier
The role of oxidative injury and inflammatory response in cardiovascular diseases and heart
failure has been well-acknowledged. This study evaluated the protective effect of …

Cardioprotective effect of taxifolin against isoproterenol-induced cardiac injury through decreasing oxidative stress, inflammation, and cell death, and activating Nrf2 …

HM Obeidat, OY Althunibat, MA Alfwuaires… - Biomolecules, 2022 - mdpi.com
Oxidative stress and inflammation are key components in cardiovascular diseases and heart
dysfunction. Herein, we evaluated the protective effects of (+)-taxifolin (TAX), a potent …

[HTML][HTML] Morin: a Comprehensive Review on its versatile Biological Activity and Associated Therapeutic potential in treating cancers

VKR Balaga, A Pradhan, R Thapa, N Patel… - Pharmacological …, 2023 - Elsevier
Introduction Herbal traditional medicines are used for the treatment of human diseases and
associated complications from the medieval periods. Flavonoids are naturally occurring …

Visnagin prevents isoproterenol‐induced myocardial injury by attenuating oxidative stress and inflammation and upregulating Nrf2 signaling in rats

MH Abukhalil, OE Hussein… - … of Biochemical and …, 2021 - Wiley Online Library
Oxidative tissue injury and inflammatory responses play major roles in cardiovascular
diseases and heart failure. Visnagin (VIS) is a natural bioactive component of Ammi visnaga …

Roles of flavonoids in ischemic heart disease: Cardioprotective effects and mechanisms against myocardial ischemia and reperfusion injury

H Xu, S Yu, C Lin, D Dong, J Xiao, Y Ye, M Wang - Phytomedicine, 2024 - Elsevier
Background Flavonoids are extensively present in fruits, vegetables, grains, and medicinal
plants. Myocardial ischemia and reperfusion (MI/R) comprise a sequence of detrimental …

The role of natural flavonoids on neuroinflammation as a therapeutic target for Alzheimer's disease: a narrative review

Q Zhang, Y Yan - Neural Regeneration Research, 2023 - journals.lww.com
Alzheimer's disease is a neurodegenerative disease that affects a large proportion of older
adult people and is characterized by memory loss, progressive cognitive impairment, and …