Multiregion neuronal activity: the forest and the trees
The past decade has witnessed remarkable advances in the simultaneous measurement of
neuronal activity across many brain regions, enabling fundamentally new explorations of the …
neuronal activity across many brain regions, enabling fundamentally new explorations of the …
A comparison of neuronal population dynamics measured with calcium imaging and electrophysiology
Calcium imaging with fluorescent protein sensors is widely used to record activity in
neuronal populations. The transform between neural activity and calcium-related …
neuronal populations. The transform between neural activity and calcium-related …
Fast and sensitive GCaMP calcium indicators for imaging neural populations
Calcium imaging with protein-based indicators is widely used to follow neural activity in
intact nervous systems. The popular GCaMP indicators are based on the calcium-binding …
intact nervous systems. The popular GCaMP indicators are based on the calcium-binding …
A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging
P Rupprecht, S Carta, A Hoffmann, M Echizen… - Nature …, 2021 - nature.com
Inference of action potentials ('spikes') from neuronal calcium signals is complicated by the
scarcity of simultaneous measurements of action potentials and calcium signals ('ground …
scarcity of simultaneous measurements of action potentials and calcium signals ('ground …
[HTML][HTML] Calcium imaging for analgesic drug discovery
F Iseppon, JE Linley, JN Wood - Neurobiology of Pain, 2022 - Elsevier
Somatosensation and pain are complex phenomena involving a rangeofspecialised cell
types forming different circuits within the peripheral and central nervous systems. In recent …
types forming different circuits within the peripheral and central nervous systems. In recent …
Reconciling functional differences in populations of neurons recorded with two-photon imaging and electrophysiology
Extracellular electrophysiology and two-photon calcium imaging are widely used methods
for measuring physiological activity with single-cell resolution across large populations of …
for measuring physiological activity with single-cell resolution across large populations of …
Neural anatomy and optical microscopy (NAOMi) simulation for evaluating calcium imaging methods
Background The past decade has seen a multitude of new in vivo functional imaging
methodologies. However, the lack of ground-truth comparisons or evaluation metrics makes …
methodologies. However, the lack of ground-truth comparisons or evaluation metrics makes …
Motor cortical influence relies on task-specific activity covariation
During limb movement, spinal circuits facilitate the alternating activation of antagonistic
flexor and extensor muscles. Yet antagonist cocontraction is often required to stabilize joints …
flexor and extensor muscles. Yet antagonist cocontraction is often required to stabilize joints …
Connectomic analysis of thalamus-driven disinhibition in cortical layer 4
Sensory signals are transmitted via the thalamus primarily to layer 4 (L4) of the primary
sensory cortices. While information about average neuronal connectivity in L4 is available …
sensory cortices. While information about average neuronal connectivity in L4 is available …
On the use of calcium deconvolution algorithms in practical contexts
Calcium imaging is a powerful tool for capturing the simultaneous activity of large
populations of neurons. Here we determine the extent to which our inferences of neural …
populations of neurons. Here we determine the extent to which our inferences of neural …