Hemidesmosomes are structural protein complexes localized at the interface of tissues with
high mechanical demand and shear forces. Beyond tissue anchoring, hemidesmosomes …

Cells are known to continuously remodel their local extracellular matrix (ECM) and in a
reciprocal way, they can also respond to mechanical and biochemical properties of their …

Simple Summary The physical properties of a tumor, such as stiffness, are important drivers
of tumor progression. However, current in vitro tumor models fail to recapitulate the full range …

The contractile apparatus, stress fiber (SF), is connected to the cell adhesion machinery,
focal adhesion (FA), at the termini of SF. The SF-FA complex is essential for various …

Fibroblasts can be directly reprogrammed via a combination of small molecules to generate
induced neurons (iNs), bypassing intermediate stages. This method holds great promise for …

Cells interpret cues from and interact with fibrous microenvironments through the body
based on the mechanics and organization of these environments and the phenotypic state of …

Liver is an essential organ that carries out multiple functions such as glycogen storage, the
synthesis of plasma proteins, and the detoxification of xenobiotics. Hepatocytes are the …

ABSTRACT WW domain-containing transcription regulator 1 (WWTR1, referred to here as
TAZ) and Yes-associated protein (YAP, also known as YAP1) are transcriptional co …

The tumor microenvironment (TME) comprises a heterogenous cell population within a
complex three-dimensional (3D) extracellular matrix (ECM). Stromal cells within this TME …

Structural alterations of collagen impact signaling that helps control tumor progression and
the responses to therapeutic intervention. Integrins represent a class of receptors that …