[HTML][HTML] CD4+ T cell memory
M Künzli, D Masopust - Nature immunology, 2023 - nature.com
Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …
peptide complexes to control phagosomal infections, help B cells, regulate tissue …
The foundations of immune checkpoint blockade and the ipilimumab approval decennial
AJ Korman, SC Garrett-Thomson… - Nature Reviews Drug …, 2022 - nature.com
Cancer immunity, and the potential for cancer immunotherapy, have been topics of scientific
discussion and experimentation for over a hundred years. Several successful cancer …
discussion and experimentation for over a hundred years. Several successful cancer …
Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers
The accurate identification of antitumor T cell receptors (TCRs) represents a major challenge
for the engineering of cell-based cancer immunotherapies. By mapping 55 neoantigen …
for the engineering of cell-based cancer immunotherapies. By mapping 55 neoantigen …
Can we predict T cell specificity with digital biology and machine learning?
Recent advances in machine learning and experimental biology have offered breakthrough
solutions to problems such as protein structure prediction that were long thought to be …
solutions to problems such as protein structure prediction that were long thought to be …
High-throughput and single-cell T cell receptor sequencing technologies
JA Pai, AT Satpathy - Nature methods, 2021 - nature.com
T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
Activation or exhaustion of CD8+ T cells in patients with COVID-19
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
Pan-peptide meta learning for T-cell receptor–antigen binding recognition
The identification of the mechanisms by which T-cell receptors (TCRs) interact with human
antigens provides a crucial opportunity to develop new vaccines, diagnostics and …
antigens provides a crucial opportunity to develop new vaccines, diagnostics and …
Deep learning-based prediction of the T cell receptor–antigen binding specificity
Neoantigens play a key role in the recognition of tumour cells by T cells; however, only a
small proportion of neoantigens truly elicit T-cell responses, and few clues exist as to which …
small proportion of neoantigens truly elicit T-cell responses, and few clues exist as to which …
PD-1-expressing SARS-CoV-2-specific CD8+ T cells are not exhausted, but functional in patients with COVID-19
Memory T cell responses have been demonstrated in COVID-19 convalescents, but ex vivo
phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2 …
phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2 …
Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening
CD4+ T cells are critical to fighting pathogens, but a comprehensive analysis of human T-
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …