Understanding mechanisms of antioxidant action in health and disease

B Halliwell - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Several different reactive oxygen species (ROS) are generated in vivo. They have roles in
the development of certain human diseases whilst also performing physiological functions …

Mechanisms of oxidative stress in metabolic syndrome

SK Masenga, LS Kabwe, M Chakulya… - International journal of …, 2023 - mdpi.com
Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus
type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to …

Hyperglycemia and oxidative stress: An integral, updated and critical overview of their metabolic interconnections

P González, P Lozano, G Ros, F Solano - International Journal of …, 2023 - mdpi.com
This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

ROS in cancer therapy: the bright side of the moon

B Perillo, M Di Donato, A Pezone, E Di Zazzo… - … & molecular medicine, 2020 - nature.com
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …

Reactive oxygen species: drivers of physiological and pathological processes

J Checa, JM Aran - Journal of Inflammation research, 2020 - Taylor & Francis
Abstract Since the Great Oxidation Event, about 2.4 billion years ago, the Earth is immersed
in an oxidizing atmosphere. Thus, it has been proposed that excess oxygen, originally a …

Reactive oxygen species (ROS) regulates different types of cell death by acting as a rheostat

GE Villalpando-Rodriguez… - Oxidative Medicine and …, 2021 - Wiley Online Library
Reactive oxygen species (ROS) are essential for cellular signaling and response to stress.
The level of ROS and the type of ROS determine the ability of cells to undergo cell death …

[HTML][HTML] Selenium stimulates the antitumour immunity: Insights to future research

A Razaghi, M Poorebrahim, D Sarhan… - European Journal of …, 2021 - Elsevier
Selenium is an essential trace element for regulating immune functions through redox-
regulating activity of selenoproteins (eg glutathione peroxidase), protecting immune cells …

Reactive oxygen species scavenging nanomedicine for the treatment of ischemic heart disease

Z Zhang, R Dalan, Z Hu, JW Wang… - Advanced …, 2022 - Wiley Online Library
Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway

BI Arioz, B Tastan, E Tarakcioglu, KU Tufekci… - Frontiers in …, 2019 - frontiersin.org
Inflammation is a crucial component of various stress-induced responses that contributes to
the pathogenesis of major depressive disorder (MDD). Depressive-like behavior (DLB) is …