Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been
considered to act only on ligand-gated receptor channels—termed NMDA, AMPA and …

Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors
activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different …

Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a
recognized, but still relatively new area of excitatory amino acid research. Current …

Electrophysiological research on mGluRs is now very extensive, and it is clear that activation
of mGluRs results in a large number of diverse cellular actions. Studies of mGluRs and on …

Movement, the fundamental component of behavior and the principal extrinsic action of the
brain, is produced when skeletal muscles contract and relax in response to patterns of action …

The nature and value of various animal models of epilepsy for the study and understanding
of the human epilepsies are reviewed, with special reference to the ILAE classification of …

The in vitro pharmacology of a structurally novel compound, LY341495, was investigated at
human recombinant metabotropic glutamate (mGlu) receptor subtypes expressed in non …

Metabotropic glutamate (mGlu) receptors have been considered as potential targets for
neuroprotective drugs, but the lack of specific drugs has limited the development of …

Paired whole-cell voltage recordings were made from synaptically connected spiny stellate
neurons in layer 4 of the barrel field in young (P14) rat somatosensory cortex. When …

Glutamate is the major excitatory neurotransmitter in the brain and plays a unique role in a
variety of central nervous system (CNS) functions. The discovery of the metabotropic …