Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Substantial research over the past two decades has established that extracellular matrix
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …

Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

Convolutions are a classical hallmark of most mammalian brains. Brain surface morphology
is often associated with intelligence and closely correlated with neurological dysfunction …

Multielectrode arrays would benefit from intimate engagement with neural cells, but typical
arrays do not present a physical environment that mimics that of neural tissues. It is …

Constitutive models are important to biomechanics for two key reasons. First, constitutive
modelling is an essential component of characterizing tissues' mechanical properties for …

There are mounting concerns surrounding the risk of neurodegenerative diseases and
complications associated with concussion incidence and repetitive head acceleration events …

Brain extracellular matrix (ECM) is complex, heterogeneous and often poorly replicated in
traditional 2D cell culture systems. The development of more physiologically relevant 3D cell …

Emerging evidence suggests that the mechanical behavior of the brain plays a critical role in
development, disease, and aging. Recent studies have begun to characterize the …