Precocious puberty is defined as the development of secondary sexual characteristics
before the age of 8 years in girls and 9 years in boys. Gonadotropin-dependent precocious …

Central precocious puberty (CPP) is characterized by early pubertal changes, acceleration
of growth velocity, and rapid bone maturation that often result in reduced adult height. An …

Purpose: Poly (lactic-co-glycolic) acid (PLGA) inserts have been successfully developed for
the treatment of posterior eye disease as a means of reducing injection frequency of …

Puberty is a critical human developmental process that leads to sexual maturation and
reproductive capability. It requires an intact hypothalamicpituitary-gonadal (HPG) axis, and …

Context: GnRH agonist (GnRHa) monthly injections are frequently used in the treatment of
central precocious puberty (CPP). The 3-month leuprolide depot 11.25-and 30-mg …

Abstract Objective Depot GnRH agonists are commonly used in the treatment of central
precocious puberty (CPP). The triptorelin 11.25 mg 3-month depot, currently used in adult …

Geoffrey Harris, while still a medical student at Cambridge, was the first researcher (1937) to
provide experimental proof for the then tentative view that the anterior pituitary gland was …

In boys, central precocious puberty (CPP) is the appearance of secondary sex
characteristics driven by pituitary gonadotropin secretion before the age of 9 years. In the …

In this chapter we discuss the development of the hypothalamic-pituitary-gonadal (HPG) axis
followed by a description of the physiology of the HPG axis, with a focus on its dynamic …

Introduction: GnRH analogs represent the drug of choice for medical treatment of central
precocious puberty (CPP). They provided prompt and reversible suppression of reproductive …