Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The loss of vital cells within healthy tissues contributes to the development, progression and
treatment outcomes of many human disorders, including neurological and infectious …

Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …

Autophagy and apoptosis are basic physiologic processes contributing to the maintenance
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …

BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …

Functional heterogeneity within tumors presents a significant therapeutic challenge. Here
we show that quiescent, therapy-resistant Sox2+ cells propagate sonic hedgehog subgroup …

Targeting oncogenic pathways holds promise for brain tumor treatment, but inhibition of
Sonic Hedgehog (SHH) signaling has failed in SHH-driven medulloblastoma. Cellular …

The family of B-cell lymphoma-2 (Bcl-2) proteins exerts key functions in cellular health. Bcl-2
primarily acts in mitochondria where it controls the initiation of apoptosis. However, during …

We report a nanoparticle formulation of the SHH-pathway inhibitor vismodegib that improves
efficacy for medulloblastoma, while reducing toxicity. Limited blood–brain barrier (BBB) …

Background While aerobic glycolysis is linked to unconstrained proliferation in cancer, less
is known about its physiological role. Why this metabolic program that promotes tumor …