The EGFR family play a significant role in cell signal transduction and their overexpression
is implicated in the pathogenesis of numerous human solid cancers. Inhibition of the EGFR …

As the result of an intricate interplay between mechanical and biochemical cues,
coordinated cell dynamics are at the basis of tissue development, homeostasis and repair …

Overexpression of the epidermal growth factor receptor (EGFR) has been linked to several
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …

Tricellular junctions are specialized cell-cell junctions formed at sites where three epithelial
or endothelial cells make contact at their apical side. By holding three cells together …

C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in
regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation …

The Src family kinases (SFK) plays an important role in multiple signal transduction
pathways. Aberrant activation of SFKs leads to diseases such as cancer, blood disorders …

The Drosophila nervous system is ensheathed by a layer of outer glial cells, the perineurial
glia, and a specialized extracellular matrix, the neural lamella. The function of perineurial …

Glial cells are essential for the proper development and functioning of the peripheral
nervous system (PNS). The ability to study the biology of glial cells is therefore critical for our …

Junctional complexes that mediate cell adhesion are key to epithelial integrity, cell division
and permeability barrier formation. In Drosophila, the scaffolding proteins Scribble (Scrib) …

Tight junctions (TJs) are cellular junctions within the mammalian epithelial cell sheet that
function as a physical barrier to molecular transport within the intercellular space …