Brucellosis vaccines: past, present and future

GG Schurig, N Sriranganathan, MJ Corbel - Veterinary microbiology, 2002 - Elsevier
The first effective Brucella vaccine was based on live Brucella abortus strain 19, a laboratory-
derived strain attenuated by an unknown process during subculture. This induces …

Recent advances in Brucella abortus vaccines

EMS Dorneles, N Sriranganathan, AP Lage - Veterinary research, 2015 - Springer
Brucella abortus vaccines play a central role in bovine brucellosis control/eradication
programs and have been successfully used worldwide for decades. Strain 19 and RB51 are …

Rough vaccines in animal brucellosis: structural and genetic basis and present status

I Moriyón, M Grilló, D Monreal, D González… - Veterinary …, 2004 - hal.science
-Brucellosis control and eradication requires serological tests and vaccines. Effective
classical vaccines (S19 in cattle and Rev 1 in small ruminants), however, induce antibodies …

Production and Targeting of the Brucella abortus Antigen L7/L12 in Lactococcus lactis: a First Step towards Food-Grade Live Vaccines against Brucellosis

LA Ribeiro, V Azevedo, Y Le Loir… - Applied and …, 2002 - Am Soc Microbiol
Brucella abortus is a facultative intracellular gram-negative bacterial pathogen that infects
humans and animals by entry mainly through the digestive tract. B. abortus causes abortion …

Protection of BALB/c Mice against Brucella abortus 544 Challenge by Vaccination with Bacterioferritin or P39 Recombinant Proteins with CpG Oligodeoxynucleotides …

A Al-Mariri, A Tibor, P Mertens, X De Bolle… - Infection and …, 2001 - Am Soc Microbiol
The P39 and the bacterioferrin (BFR) antigens of Brucella melitensis 16M were previously
identified as T dominant antigens able to induce both delayed-type hypersensivity in …

Proteomic analysis of Brucella abortus cell envelope and identification of immunogenic candidate proteins for vaccine development

JP Connolly, D Comerci, TG Alefantis, A Walz… - …, 2006 - Wiley Online Library
Brucella abortus is the etiologic agent of bovine brucellosis and causes a chronic disease in
humans known as undulant fever. In livestock the disease is characterized by abortion and …

Immune response triggered by Brucella abortus following infection or vaccination

EMS Dorneles, A Teixeira-Carvalho, MSS Araújo… - Vaccine, 2015 - Elsevier
Brucella abortus live vaccines have been used successfully to control bovine brucellosis
worldwide for decades. However, due to some limitations of these live vaccines, efforts are …

Brucellosis vaccines for livestock

ZI Goodwin, DW Pascual - Veterinary immunology and immunopathology, 2016 - Elsevier
Brucellosis is a livestock disease responsible for fetal loss due to abortions. Worldwide, this
disease has profound economic and social impact by reducing the ability of livestock …

Immune Response to Mucosal Brucella Infection

R López-Santiago, AB Sánchez-Argáez… - Frontiers in …, 2019 - frontiersin.org
Brucellosis is one of the most prevalent bacterial zoonosis of worldwide distribution. The
disease is caused by Brucella spp., facultative intracellular pathogens. Brucellosis in …

A DNA Vaccine Encoding Cu,Zn Superoxide Dismutase of Brucella abortus Induces Protective Immunity in BALB/c Mice

AA Onate, S Cespedes, A Cabrera, R Rivers… - Infection and …, 2003 - Am Soc Microbiol
This study was conducted to evaluate the immunogenicity and protective efficacy of a DNA
vaccine encoding Brucella abortus Cu, Zn superoxide dismutase (SOD). Intramuscular …