Chitin and chitosan are two related polysaccharides that provide important structural stability
to fungal cell walls. Often embedded deeply within the cell wall structure, these molecules …

The plasma membrane (PM) performs a plethora of physiological processes, the
coordination of which requires spatial and temporal organization into specialized domains of …

Cryptococcus spp. are environmental fungi that first must adapt to the host environment
before they can cause life-threatening meningitis in immunocompromised patients. Host …

Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …

Fungi often adapt to environmental stress by altering their size, shape, or rate of cell division.
These morphological changes require reorganization of the cell wall, a structural feature …

During mammalian colonization and infection, microorganisms must be able to rapidly
sense and adapt to changing environmental conditions including alterations in extracellular …

Fungi can cause devastating invasive infections, typically in immunocompromised patients.
Treatment is complicated both by the evolutionary similarity between humans and fungi and …

The ability for cells to maintain homeostasis in the presence of extracellular stress is
essential for their survival. Stress adaptations are especially important for microbial …

Fungal infections in humans are difficult to treat, with very limited drug options. Due to a
confluence of factors, there is an urgent need for innovation in the antifungal drug space …

Human studies have shown associations between cryptococcal meningitis and reduced IgM
memory B cell levels, and studies in IgM-and/or B cell-deficient mice have demonstrated …