Lines of evidence from several studies have shown that increases in life expectancy are now
accompanied by increased disability rate. The expanded lifespan of the aging population …

Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great
volume of knowledge in the field has been accumulated. Here we attempted to organize the …

DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is
based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel …

Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …

Mammals have evolved a remarkable diversity of ageing rates. Within the single order of
Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats …

Mammals differ more than 100‐fold in maximum lifespan, which can be altered in either
direction during evolution, but the molecular basis for natural changes in longevity is not …

A large amount of the longevity-modulating genes discovered during the last two decades
are highly conserved during evolution from yeast and invertebrates to mammals. Many …

DNA double-strand breaks (DSBs) are a hazardous form of damage that can potentially
cause cell death or genomic rearrangements. In mammalian G1-and G2-phase cells, DSBs …

Telomeres are highly conserved regions of DNA that protect the ends of linear
chromosomes. The loss of telomeres can signal an irreversible change to a cell's state …

Telomere maintenance is essential for maintaining genome integrity in both normal and
cancer cells. Without functional telomeres, chromosomes lose their protective structure and …