Hypoxia‐induced phrenic long‐term facilitation: emergent properties

MJ Devinney, AG Huxtable, NL Nichols… - Annals of the New …, 2013 - Wiley Online Library
As in other neural systems, plasticity is a hallmark of the neural system controlling breathing.
One spinal mechanism of respiratory plasticity is phrenic long‐term facilitation (pLTF) …

Is there a link between intermittent hypoxia‐induced respiratory plasticity and obstructive sleep apnoea?

S Mahamed, GS Mitchell - Experimental physiology, 2007 - Wiley Online Library
Although neuroplasticity is an important property of the respiratory motor control system, its
existence has been appreciated only in recent years and, as a result, its functional …

Repetitive intermittent hypoxia induces respiratory and somatic motor recovery after chronic cervical spinal injury

MR Lovett-Barr, I Satriotomo, GD Muir… - Journal of …, 2012 - Soc Neuroscience
Spinal injury disrupts connections between the brain and spinal cord, causing life-long
paralysis. Most spinal injuries are incomplete, leaving spared neural pathways to motor …

Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics

RD Brust, AE Corcoran, GB Richerson, E Nattie… - Cell reports, 2014 - cell.com
Serotonergic neurons modulate behavioral and physiological responses from aggression
and anxiety to breathing and thermoregulation. Disorders involving serotonin (5HT) …

Episodic spinal serotonin receptor activation elicits long‐lasting phrenic motor facilitation by an NADPH oxidase‐dependent mechanism

PM MacFarlane, GS Mitchell - The Journal of physiology, 2009 - Wiley Online Library
Phrenic long‐term facilitation (pLTF) is a serotonin (5‐HT)‐dependent augmentation of
phrenic motor output induced by acute intermittent hypoxia (AIH). AIH‐induced pLTF …

Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus

I Satriotomo, EA Dale, JM Dahlberg, GS Mitchell - Experimental neurology, 2012 - Elsevier
Acute intermittent hypoxia (AIH) initiates plasticity in respiratory motor control, including
phrenic long term facilitation (pLTF). Since pLTF is enhanced by preconditioning with …

Intermittent hypoxia induces functional recovery following cervical spinal injury

S Vinit, MR Lovett-Barr, GS Mitchell - Respiratory physiology & …, 2009 - Elsevier
Respiratory-related complications are the leading cause of death in spinal cord injury (SCI)
patients. Few effective SCI treatments are available after therapeutic interventions are …

[HTML][HTML] Dry eye syndrome, posttraumatic stress disorder, and depression in an older male veteran population

CA Fernandez, A Galor, KL Arheart… - … & visual science, 2013 - tvst.arvojournals.org
Purpose.: To evaluate whether veterans with posttraumatic stress disorder (PTSD) or
depression have differences in dry eye symptoms and signs compared to a population …

Chronic intermittent hypoxia reduces ventilatory long-term facilitation and enhances apnea frequency in newborn rats

C Julien, A Bairam, V Joseph - American Journal of …, 2008 - journals.physiology.org
Ventilatory long-term facilitation (LTF; defined as gradual increase of minute ventilation
following repeated hypoxic exposures) is well described in adult mammals and is …

Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized rats

TL Baker-Herman, GS Mitchell - Respiratory physiology & neurobiology, 2008 - Elsevier
Acute intermittent (AIH), but not acute sustained hypoxia (ASH) elicits a form of respiratory
plasticity known as long-term facilitation (LTF). In anesthetized rats, LTF is expressed as …