Emerging preclinical findings have indicated that steroid hormone receptor signaling plays
an important role in bladder cancer outgrowth. In particular, androgen-mediated androgen …

Men are three to four times more likely to get bladder cancer than women. The gender
disparity characterizing bladder cancer diagnoses has been investigated. One hypothesis is …

Approximately 50% of patients with muscle-invasive bladder cancer (MIBC) develop
metastatic disease, which is almost invariably lethal. However, our understanding of …

Background Emerging preclinical evidence suggests a critical role for androgen-mediated
androgen receptor (AR) signaling in bladder cancer progression. However, researchers …

In vitro generation of human urothelium from stem cells would be a major advancement in
the regenerative medicine field, providing alternate nonurologic and/or nonautologous …

Men have had a substantially higher risk of developing bladder cancer than women. This
has prompted research on androgen-mediated androgen receptor (AR) signaling in …

Genomic and transcriptional studies have identified discrete molecular subtypes of bladder
cancer. These observations could be the starting point to identify new treatments. Several …

Differentiation is defined as the ability of a cell to acquire full functional behavior. For
instance, the function of bladder urothelium is to act as a barrier to the diffusion of solutes …

Urothelial cells play essential roles in protection of urine exudation and bacterial invasion at
the urothelial mucosa, so that defect or damage of urothelial cells associated with urinary …

Bladder regeneration is a long-sought goal that could provide alternatives to cystoplasty
using non-urological tissues. Regeneration might be achieved in different ways, such as …