Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor
that triggers intracellular protein tyrosine phosphorylation. Recent genome-wide association …

TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

Microglia, the principal neuroimmune sentinels of the brain, continuously sense changes in
their environment and respond to invading pathogens, toxins and cellular debris. Microglia …

Dysfunction of microglia, the tissue macrophages of the brain, has been associated with the
etiology of several neuropsychiatric disorders. Consistently, microglia have been shown to …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most
common cause of dementia. Deposition of amyloid‐β (Aβ) remains a hallmark feature of the …

Microglia are resident immune cells of the CNS that are activated by infection, neuronal
injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of …

Microglia are activated after neuronal injury and in neurodegenerative diseases, and trigger
neuroinflammation in the central nervous system (CNS). Microglia-derived …

Microglia are resident brain cells that sense pathological tissue alterations. They can
develop into brain macrophages and perform immunological functions. However …