Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

The cardiac extracellular matrix (ECM) is a complex architectural network consisting of
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …

Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a
result of cardiac fibroblast (CFB) activation and differentiation into myofibroblasts …

The development and progression of cardiovascular disease (CVD) can mainly be attributed
to the narrowing of blood vessels caused by atherosclerosis and thrombosis, which induces …

Cardiac fibrosis, the excessive accumulation of extracellular matrix (ECM), remains an
unresolved problem in most forms of heart disease. In order to be successful in preventing …

Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

In healing wounds and fibrotic lesions, fibroblasts and monocyte-derived fibroblast-like cells
called fibrocytes help to form scar tissue. Although fibrocytes promote collagen production …

Extracellular matrix remodeling is extensive in several heart diseases and hampers cardiac
filling, often leading to heart failure. Proteoglycans have over the last two decades emerged …

Background Fibroproliferative repair starts early in the inflammatory phase of acute
respiratory distress syndrome (ARDS) and indicates a poor prognosis. Lumican, a small …