Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or
damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction …

The trabecular meshwork (TM) is located in the anterior segment of the eye and is
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …

Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …

Glaucoma is a progressive and chronic neurodegenerative disorder characterized by
damage to the inner layers of the retina and deformation of the optic nerve head. The …

Alterations in stiffness of the trabecular meshwork (TM) may play an important role in primary
open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain …

Despite advances in surgical technique and postoperative care, fibrosis remains the major
impediment to a marked reduction of intraocular pressure without the need of additional …

Scarring and tissue fibrosis represent a significant source of morbidity in the United States.
Despite considerable research focused on elucidating the mechanisms underlying …

Rationale: Optic neuritis is one of main symptoms in multiple sclerosis (MS) that causes
visual disability. Astrocytes are pivotal regulators of neuroinflammation in MS, and astrocytic …

Purpose: Treatment with corticosteroids can result in ocular hypertension and may lead to
the development of steroid-induced glaucoma. The extent to which biomechanical changes …

Although glaucoma is a relatively common blinding disease, most people do not develop
glaucoma. A robust intraocular pressure (IOP) homeostatic mechanism keeps ocular …