Stem cells have the ability to self-renew and differentiate along multiple lineages, driving
tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical …

All adult tissues experience wear and tear. Most tissues can compensate for cell loss
through the activity of resident stem cells. Although the cellular maintenance strategies vary …

Tissue homeostasis requires the production of newly differentiated cells from resident adult
stem cells. Central to this process is the expansion of undifferentiated intermediates known …

Epithelial cells that participated in wound repair elicit a more efficient response to future
injuries, which is believed to be locally restricted. Here we show that cell adaptation …

Stem cells (SCs) govern tissue homeostasis and wound repair. They reside within niches,
the special microenvironments within tissues that control SC lineage outputs. Upon injury or …

Aging manifests with architectural alteration and functional decline of multiple organs
throughout an organism. In mammals, aged skin is accompanied by a marked reduction in …

Normal tissue responses to ionizing radiation have been a major subject for study since the
discovery of X‐rays at the end of the 19th century. Shortly thereafter, time–dose relationships …

Dysfunction of the salivary gland and irreversible hyposalivation are the main side effects of
radiotherapy treatment for head and neck cancer leading to a drastic decrease of the quality …

The classical model of tissue renewal posits that small numbers of quiescent stem cells
(SCs) give rise to proliferating transit-amplifying cells before terminal differentiation …

Highly sensitive DNA sequencing techniques have allowed the discovery of large numbers
of somatic mutations in normal tissues. Some mutations confer a competitive advantage over …