Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

Aging is a complex biological process and represents the largest risk factor for
neurodegenerative disorders. The risk for neurodegenerative disorders is also increased in …

The mammalian brain is composed of many brain structures, each with its own ontogenetic
and developmental history. We used single-nucleus RNA sequencing to sample over 2.4 …

The genetic basis of schizophrenia (SZ) remains elusive despite its characterization as a
highly heritable disorder. This incomplete understanding has led to stagnation in …

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular
anatomy of the human dorsolateral prefrontal cortex - PMC Back to Top Skip to main content NIH …

The molecular organization of the human neocortex historically has been studied in the
context of its histological layers. However, emerging spatial transcriptomic technologies …

Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major
depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease …

The increase in publicly available human single-cell datasets, encompassing millions of
cells from many donors, has significantly enhanced our understanding of complex biological …

The omnigenic model posits that genetic risk for traits with complex heritability involves
cumulative effects of peripheral genes on mechanistic" core genes," suggesting that in a …

In a previous study on ionotropic glutamate receptors, we have shown that [3 H] kainate, but
not [3 H] AMPA or [3 H] NMDA, receptor binding was lower in Brodmann's area (BA) 9 from …