Glutamatergic signaling along the microbiota-gut-brain axis

A Baj, E Moro, M Bistoletti, V Orlandi, F Crema… - International journal of …, 2019 - mdpi.com
A complex bidirectional communication system exists between the gastrointestinal tract and
the brain. Initially termed the “gut-brain axis” it is now renamed the “microbiota-gut-brain …

Role of microbiota and tryptophan metabolites in the remote effect of intestinal inflammation on brain and depression

B Waclawiková, S El Aidy - Pharmaceuticals, 2018 - mdpi.com
The human gastrointestinal tract is inhabited by trillions of commensal bacteria collectively
known as the gut microbiota. Our recognition of the significance of the complex interaction …

Enteric glia: the most alimentary of all glia

V Grubišić, BD Gulbransen - The Journal of physiology, 2017 - Wiley Online Library
Glia (from Greek γλοία meaning 'glue') pertains to non‐neuronal cells in the central (CNS)
and peripheral nervous system (PNS) that nourish neurons and maintain homeostasis. In …

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation

F Alhasson, S Das, R Seth, D Dattaroy… - PloS one, 2017 - journals.plos.org
Many of the symptoms of Gulf War Illness (GWI) that include neurological abnormalities,
neuroinflammation, chronic fatigue and gastrointestinal disturbances have been traced to …

Role of glutamatergic neurotransmission in the enteric nervous system and brain-gut axis in health and disease

V Filpa, E Moro, M Protasoni, F Crema, G Frigo… - …, 2016 - Elsevier
Several studies have been carried out in the last 30 years in the attempt to clarify the
possible role of glutamate as a neurotransmitter/neuromodulator in the gastrointestinal tract …

The microbiota-gut-brain axis: Focus on the fundamental communication pathways

M Bistoletti, A Bosi, D Banfi, C Giaroni, A Baj - Progress in molecular …, 2020 - Elsevier
The existence of a bidirectional communication system termed the “gut-brain axis” linking
the gastrointestinal tract with the brain has been recognized since the nineteenth century. In …

Enteric glia regulate gut motility in health and disease

V Grubišić, A Verkhratsky, R Zorec, V Parpura - Brain research bulletin, 2018 - Elsevier
The enteric nervous system, often referred to as the second brain, is the largest assembly of
neurons and glia outside the central nervous system. The enteric nervous system resides …

[HTML][HTML] Enteric glial cells and their role in gastrointestinal motor abnormalities: introducing the neuro-gliopathies

G Bassotti, V Villanacci, S Fisogni, E Rossi… - World Journal of …, 2007 - ncbi.nlm.nih.gov
The role of enteric glial cells has somewhat changed from that of mere mechanical support
elements, gluing together the various components of the enteric nervous system, to that of …

N‐Methyl‐d‐aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat

G Varga, D Érces, B Fazekas, M Fülöp… - …, 2010 - Wiley Online Library
Background Inflammatory bowel diseases are accompanied by severe motility disorders.
The aim of our study was to investigate whether the blockade of peripheral N‐methyl‐D …

The enteric glia and its modulation by the endocannabinoid system, a new target for cannabinoid-based nutraceuticals?

L López-Gómez, A Szymaszkiewicz, M Zielińska… - Molecules, 2022 - mdpi.com
The enteric nervous system (ENS) is a part of the autonomic nervous system that intrinsically
innervates the gastrointestinal (GI) tract. Whereas enteric neurons have been deeply …