Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Cells are constantly submitted to external mechanical stresses, which they must withstand
and respond to. By forming a physical boundary between cells and their environment that is …

Malignancy is associated with changes in cell mechanics that contribute to extensive cell
deformation required for metastatic dissemination. We hypothesized that the cell-intrinsic …

In the context of development, tissue homeostasis, immune surveillance, and pathological
conditions such as cancer metastasis and inflammation, migrating amoeboid cells …

Migratory cells use distinct motility modes to navigate different microenvironments, but it is
unclear whether these modes rely on the same core set of polarity components. To …

Membrane blebbing accompanies various cellular processes, including cytokinesis,
apoptosis, and cell migration, especially invasive migration of cancer cells. Blebs are …

Soft-condensed matter physics has provided, in the past decades, many of the relevant
concepts and methods allowing successful description of living cells and biological tissues …

Cells spread on surfaces and within three-dimensional (3-D) matrixes as they grow, divide,
and move. Both chemical and physical signals orchestrate spreading during normal …

The asymmetric divisions of Drosophila neural stem cells (NSCs) produce unequally sized
siblings, with most volume directed into the sibling that retains the NSC fate. Sibling size …

To study the mechanisms controlling front-rear polarity in migrating cells, we used zebrafish
primordial germ cells (PGCs) as an in vivo model. We find that polarity of bleb-driven …